C - Chemistry – Metallurgy – 07 – J
Patent
C - Chemistry, Metallurgy
07
J
C07J 63/00 (2006.01) A61K 31/56 (2006.01) A61P 31/14 (2006.01) A61P 31/18 (2006.01) C07J 53/00 (2006.01)
Patent
CA 2499038
Betulin and dihydrobetulin acyl derivatives according to the present invention have been found to have potent anti-HIV activity. The compounds of the present invention have Formula I as described herein, or pharmaceutically acceptable salts thereof; wherein R1 is a C2-C20 substituted or unsubstituted carboxyacyl, R2 is hydrogen, chloro, bromo, or hydroxy, R4 is hydrogen or C(C6H5)3; wherein the dashed line represents an optional double bond between C20 and C29.
L'invention concerne des dérivés acylés de la bétuline et de la dihydrobétuline possédant une puissante activité anti-VIH. Les composés selon l'invention sont de formule I telle que décrite dans la description, ou des sels acceptables sur le plan pharmaceutique de ceux-ci; dans laquelle R1 représente un carboxyacyle en C2-C20 substitué ou non substitué, R2 désigne un hydrogène, un chloro, un bromo ou un hydroxy, R4 représente un hydrogène ou C(C6H5)3; dans laquelle la ligne pointillée désigne une liaison double facultative entre C20 et C29.
Allaway Graham P.
Kashiwada Yoshiki
Lee Kuo-Hsiung
Wild Carl T.
Mbm Intellectual Property Law Llp
Niigata University Of Pharmacy And Applied Life Sciences
Panacos Pharmaceuticals Inc.
The University Of North Carolina At Chapel Hill
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