C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 281/10 (2006.01) A61K 31/16 (2006.01) A61K 31/175 (2006.01) A61K 31/21 (2006.01) A61K 31/27 (2006.01) A61K 31/275 (2006.01) C07C 251/80 (2006.01) C07C 251/86 (2006.01) C07C 255/66 (2006.01) C07C 271/14 (2006.01) C07C 281/04 (2006.01)
Patent
CA 2180956
Novel monoamine oxidase B inhibitors of formula (I), wherein R¿1? = H, an optionally substituted benzyloxy or phenylethoxy group; p = 0-3; R¿3? = H, a CN, OH, CCH group, a C¿1?-C¿3? alkoxy-carbonyl group, or a C¿1?-C¿3? alkylated cyanomethyl group; R¿2? = H or a C¿1?-C¿3? alkyl group; n = 0 or 1; if n = 0, R¿4? is a C¿1?-C¿3? alkyl group or a C¿1?-C¿3? alkoxy group, while if n = 1, y = 1 and R¿4? is a C¿1?-C¿3? alkyl group, a C¿1?-C¿3? alkoxy group or a phenyl group. The invention also concerns processes for the preparation of said novel inhibitors and the therapeutic use thereof.
L'invention se rapporte à de nouveaux inhibiteurs de la Monoamine Oxydase B qui répondent à la formule (I), dans laquelle: R1 = H, groupe benzyloxy ou phényléthoxy éventuellement substitué; p = 0 à 3; R3 = H, groupe CN, OH, CCH, alcoxy-carbonyle en C1 à C3 ou alkylé en C1 à C3 de cyanométhyle; R2 = H ou groupe alkyle en C1 à C3; n = 0 ou 1 avec, quand n = 0, R4 = groupe alkyle en C1 à C3 ou alcoxy en C1 à C3, tandis que quand n = 1, y = 1 et R4 = groupe alkyle en C1 à C3, alcoxy en C1 à C3 ou phényle. Leurs procédés de préparation et leurs applications en thérapeutique.
Bernard Suzanne
Milcent Rene
Paillat Catherine
Seman Michel
Borden Ladner Gervais Llp
Laboratoires Mayoly Spindler
Seman Michel
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