Monoamine oxidase (mao) inhibitors and uses thereof

Details Monoamine oxidase (mao) inhibitors and uses thereof Monoamine oxidase (mao) inhibitors and uses thereof

A - Human Necessities

61

K

A61K 31/4545 (2006.01) A61K 31/4439 (2006.01) A61P 25/04 (2006.01) A61P 25/14 (2006.01) A61P 25/16 (2006.01) A61P 25/22 (2006.01) A61P 25/24 (2006.01) A61P 25/28 (2006.01) A61P 25/30 (2006.01) A61P 43/00 (2006.01) C07D 401/04 (2006.01)

Patent

CA 2334186

The present invention provides a group of tobacco alkaloids, tobacco extract, Yerbamaté extract, and an extract of chewing gum and lozenges which are modulators of monoamine oxidase (MAO) activity (i.e., compounds and substances which inhibit MAO enzyme and prevent its biological activity). The MAO inhibitors of the present invention can cause an increase in the level of norepinephrine, dopamine, and serotonin in the brain and other tissues, and thus can cause a wide variety of pharmacological effects mediated by their effects on these compounds. The MAO inhibitors of the present invention are useful for a variety of therapeutic applications, such as the treatment of depression, disorders of attention and focus, mood and emotional disorders, Parkinson's disease, extrapyramidal disorders, hypertension, substance abuse, smoking substitution, antidepression therapy, eating disorders, withdrawal syndromes, and the cessation of smoking.

La présente invention concerne un groupe d'alcaloïdes de tabac, d'un extrait de tabac, d'un extrait de Yerbamaté, et d'un extrait de gomme à mâcher et de losanges, qui sont des modulateurs de l'activité de la monoamine oxydase (MAO) (c'est-à-dire des composés et des substances inhibant l'enzyme MAO et prévenant son activité biologique). Les inhibiteurs de MAO de la présente invention peuvent causer une augmentation du niveau de noradrénaline, de dopamine, et de sérotonine dans le cerveau et dans d'autres tissus, et ainsi avoir de nombreux effets pharmacologiques, en raison de leur action sur ces composés. Les inhibiteurs de MAO de la présente invention peuvent être utilisés dans de nombreuses applications thérapeutiques, par exemple pour traiter la dépression, les troubles de l'attention et de la concentration, les troubles de l'humeur et les perturbations affectives, la maladie de Parkinson, les troubles extrapyramidaux, l'hypertension, les abus de substances psychoactives, le besoin de fumer, la thérapie contre les états dépressifs, les troubles de l'alimentation, les syndromes de sevrage, et la désaccoutumance au tabac.

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