C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 311/20 (2006.01) A61K 31/18 (2006.01) A61K 31/40 (2006.01) A61P 11/00 (2006.01) C07C 311/29 (2006.01) C07D 207/12 (2006.01)
Patent
CA 2732210
The invention is concerned with the compounds of formula (I): and pharmaceutically acceptable salts and esters thereof, wherein R1, R2 and R3 are defined in the detailed description and claims. In addition, the present invention relates to methods of manufacturing and using the compounds of formula (I) as well as pharmaceutical compositions containing such compounds. The compounds of formula (I) are antagonists at the CRTH2 receptor and may be useful in treating diseases and disorders associated with that receptor such as asthma.
L'invention concerne les composés de la formule (I) et des sels et des esters de qualité pharmaceutique de ceux-ci, R1, R2 et R3 étant définis dans la description et les revendications. De plus, la présente invention concerne des procédés de fabrication et d'utilisation des composés de la formule (I), ainsi que des compositions pharmaceutiques contenant de tels composés. Les composés de la formule (I) sont des antagonistes du récepteur CRTH2 et peuvent sutiliser dans le traitement de maladies et de troubles associés à ce récepteur, tels que l'asthme.
Blanc Jean-Baptiste
Chen Li
Firooznia Fariborz
Gillespie Paul
Goodnow Robert Alan Jr.
Borden Ladner Gervais Llp
F. Hoffmann-La Roche Ag
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