Monobasic phenalkylamide derivatives as antiarrhythmic agents

Details Monobasic phenalkylamide derivatives as antiarrhythmic agents Monobasic phenalkylamide derivatives as antiarrhythmic agents

C - Chemistry, Metallurgy

07

D

167/232, 167/233

C07D 207/27 (2006.01) C07D 295/14 (2006.01) C07D 295/145 (2006.01) C07D 295/18 (2006.01) C07D 295/185 (2006.01)

Patent

CA 1261846

Abstract of the Disclosure Compositions of matter are disclosed of compounds of the formula Image and the pharmaceutically acceptable acid addition salts thereof wherein X represents a halo, lower alkyl, hydrogen, trifluoromethyl, phenyl, or lower alkoxy substituent; Y represents -CN, -CONH2, -CON(R1)2 or -CO2R1 where R1 is a lower alkyl; m is the integer 1 or 2 and n is an integer from 1 to 3 inclusive; R2 represents lower alkyl; R3 represents lower alkyl or acetyl, aroyl, phenacetyl or trifluoracetyl; A, B, and D are carbonyl or methylene such that when one of A, B, or D is carbonyl, the others are methylene and R3 is lower alkyl, whereas when R3 is acetyl, aroyl, phenacetyl or trifluoroacetyl, A, B, and D are methylene. These compounds have utility as antiarrhythmic agents.

486464

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