Monoclonal and cdr-grafted antibodies specific for human kdr

Details Monoclonal and cdr-grafted antibodies specific for human kdr Monoclonal and cdr-grafted antibodies specific for human kdr

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A61K 39/395 (2006.01) A61K 47/30 (2006.01) A61K 47/48 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) C07K 16/28 (2006.01) C12N 15/70 (2006.01) C12P 21/02 (2006.01) C12P 21/08 (2006.01)

Patent

CA 2458464

There are disclosed antibody molecules containing at least one CDR derived from a mouse monoclonal antibody having specificity for human KDR. There is also disclosed a CDR grafted antibody wherein at least one of the CDRs is a hybrid CDR. Further disclosed are DNA sequences encoding the chains of the antibody molecules, vectors, transformed host cells and uses of the antibody molecules in the treatment of diseases in which VEGF and/or KDR are implicated.

L'invention a trait à des molécules d'anticorps contenant au moins une région déterminante de la complémentarité (CDR) dérivée d'un anticorps monoclonal d'une souris présentant une spécificité pour le récepteur KDR humain. L'invention concerne également un anticorps greffé sur une CDR dans laquelle au moins une des CDR est une CDR hybride. En outre, l'invention concerne des séquences d'ADN codant des chaînes de molécules d'anticorps, des vecteurs, des cellules hôtes transformées et des utilisations des molécules d'anticorps dans le traitement de maladies dans lesquelles le facteur de croissance VEGF et/ou les récepteurs KDR sont impliqués.

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