Monoclonal and chimeric antibodies specific for human tumor...

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 16/24 (2006.01) A61K 39/395 (2006.01) C07K 16/46 (2006.01) C12N 15/13 (2006.01)

Patent

CA 2324853

Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-.alpha. (TNF.alpha.) and are useful in vivo diagnosis and therapy of a number of TNF.alpha.-mediated pathologies and conditions, as well as polynucleotides coding for murine and chimeric antibodies, methods of producing the antibody, methods of use of the anti-TNF antibody, or fragment, region or derivative thereof, in immunoassays and immunotherapeutic approaches are provided.

L'invention porte sur des anticorps dirigés contre le TNF, des fragments et des régions de ceux- ci, spécifiques au TNF-alpha et utiles pour le diagnostic in vivo et le traitement de plusieurs affections où le TNF-alpha joue un rôle, des polynucléotides codant des anticorps murins et des anticorps chimères, des méthodes permettant de produire l'anticorps, des utilisations de l'anticorps anti-TNF, du fragment, d'une région ou d'un dérivé de celui-ci dans des immuno- essais, et des approches immunothérapeutiques.

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