C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/31 (2006.01) A61K 39/085 (2006.01) A61K 39/395 (2006.01) A61K 39/40 (2006.01) A61P 31/04 (2006.01) C07K 14/31 (2006.01) C07K 16/12 (2006.01) G01N 33/569 (2006.01)
Patent
CA 2478029
Monoclonal and polyclonal antibodies are provided which recognize and bind to the SdrG protein of S. epidermidis, and more particularly to antibodies which recognize specific domains of the SdrG protein, namely the SdrG N1N2N3 protein (amino acids 50-597), the SdrG N2N3 protein (amino acids 273-597) and a truncated version of N2N3 identified as SdrG TR2 (amino, acids 273-577). The antibodies of the invention, as well as pharmaceutical compositions incorporating these antibodies, are particularly useful in treating or preventing infections caused by coagulase-negative staphylococci.
L'invention concerne des anticorps monoclonaux et polyclonaux qui reconnaissent et se fixent à la protéine SdrG de S. epidermidis, et particulièrement à des anticorps qui reconnaissent des domaines spécifiques de la protéine SdrG, appelée la protéine SdrG N1N2N3 (aminoacides 50-597), ladite protéine SdrG N2N3 (aminoacides 273-597) et une version tronquée de N2N3 identifiée comme SdrG TR2 (aminoacides 273-577). Les anticorps de l'invention, ainsi que des compositions pharmaceutiques incorporant lesdits anticorps, sont particulièrement utiles dans le traitement et la prévention d'infections provoquées par des staphylocoques à coagulase négative.
Bowden Maria G.
Domanski Paul
Hall Andrea
Hook Magnus
Hutchins Jeff T.
Inhibitex Inc.
Mccarthy Tetrault Llp
The Texas A. & M. University System
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