C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/28 (2006.01) A61P 31/14 (2006.01)
Patent
CA 2738027
The present invention provides monoclonal antibodies that specifically bind to the extracellular domain of human Claudin-1 on the cell surface, thereby inhibiting HCV entry into susceptible cells and preventing HCV infection of these cells; and hybridoma cell lines which produce such monoclonal antibodies. Also provided are reagents that comprise such antibodies, and pharmaceutical compositions comprising such antibodies. Methods of treating or preventing HCV infection by administration of an inventive monoclonal antibody, or a pharmaceutical composition thereof are also described.
L'invention concerne des anticorps monoclonaux se liant spécifiquement au domaine extracellullaire de la claudine 1 humaine sur la surface cellulaire, ce qui inhibe la pénétration du virus de l'hépatite C dans les cellules susceptibles et empêche ce virus d'infecter les cellules en question; et des lignées cellulaires d'hybridome produisant les anticorps en question. On décrit aussi des réactifs comprenant de tels anticorps, et des compositions pharmaceutiques les renfermant également. L'invention concerne enfin des procédés de traitement ou de prévention de ladite infection par administration d'anticorps monoclonal selon l'invention, ou une composition pharmaceutique correspondante.
Baumert Thomas
Grunert Fritz
Schuster Catherine
Thompson John
Genovac
Inserm (institut National de La Sante Et de La Recherche Medical
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Universite de Strasbourg
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