Monoclonal anti-human breast cancer antibodies

Details Monoclonal anti-human breast cancer antibodies Monoclonal anti-human breast cancer antibodies

C - Chemistry, Metallurgy

12

P

167/129, 167/45,

C12P 21/00 (2006.01) A61K 39/395 (2006.01) C12N 5/00 (2006.01)

Patent

CA 1253090

Abstract of the Disclosure Murine monoclonal antibodies are prepared and characterized which bind selectively to human breast cancer cells, are IgGs or IgMs, and when conjugated to ricin A chain, exhibit a TCID 50% against at least one of MCF-7, CAMA-1, SKBR-3, or BT-20 cells of less than about 10 nM. Methods for diagnosing, monitoring, and treating human breast cancer with the antibodies or immunotoxins made therefrom are described.

472301

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