Monoclonal antibodies against extracellular loops of c5ar

Details Monoclonal antibodies against extracellular loops of c5ar Monoclonal antibodies against extracellular loops of c5ar

C - Chemistry, Metallurgy

07

K

C07K 16/28 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61K 48/00 (2006.01) A61P 37/02 (2006.01) C12N 5/16 (2006.01) C12N 5/20 (2006.01) C12N 15/13 (2006.01) C12N 15/87 (2006.01) G01N 33/53 (2006.01) G01N 33/567 (2006.01)

Patent

CA 2476773

The present invention relates to antibodies which bind to C5aR and which are useful in diagnostic and therapeutic methods. The antibodies of the present invention are reactive with an extracellular loop of C5aR other than the N- terminal domain and are capable of substantially reducing or inhibiting the binding of C5a to C5aR and functional consequences of neutrophil chemoattractant receptor activation.

La présente invention concerne des anticorps se liant à C5aR et servant dans des procédés diagnostiques et thérapeutiques. Lesdits anticorps réagissent avec une boucle extracellulaire de C5aR différente du domaine N-terminal, et sont capables de réduire ou d'inhiber sensiblement la liaison de C5a à C5aR, ainsi que des conséquences fonctionnelles de l'activation de récepteurs neutrophiles chiomiotactiques.

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