Monoclonal antibodies against hmgb1

Details Monoclonal antibodies against hmgb1 Monoclonal antibodies against hmgb1

C - Chemistry, Metallurgy

07

K

C07K 16/18 (2006.01) A61K 39/395 (2006.01) C12N 5/20 (2006.01)

Patent

CA 2538763

In various embodiments, the present invention is drawn to antibodies or antigen-binding fragments thereof that bind to a vertebrate high mobility group box (HMGB) polypeptide, methods of detecting and/or identifying an agent that binds to an HMGB polypeptide, methods of treating a condition in a subject characterized by activation of an inflammatory cytokine cascade and methods of detecting an HMGB polypeptide in a sample.

L'invention concerne divers modes de réalisation dans lesquels on décrit des anticorps ou leurs fragments de liaison à l'antigène, qui se lient à un polypeptide de la famille des protéines HMGB chez un vertébré. Elle concerne également des méthodes de détection et/ou d'identification d'un agent qui se lie à un polypeptide HMGB; des méthodes de traitement d'une pathologie chez un sujet caractérisées par l'activation d'une cascade de la cytokine inflammatoire; et des méthodes de détection d'un polypeptide HMGB dans un prélèvement.

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