C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) C07K 16/18 (2006.01) C12P 21/08 (2006.01) G01N 33/53 (2006.01) G01N 33/574 (2006.01) G01N 33/577 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2356595
Monoclonal antibodies specifically recognizing a human apoptosis inhibitory protein NAIP having the amino acid sequence represented by SEQ ID NO:1 which are anti-NAIP monoclonal antibodies produced respectively by hybridomas prepared by fusing antibody-producing cells of mammals immunized with immunogens containing a polypeptide comprising the amino acid sequence consisting of the amino acids of the numbers 256 to 586 in SEQ ID NO:1 or a polypeptide comprising the amino acid sequence consisting of the amino acids of the numbers 841 to 1052 in SEQ ID NO:1 or parts thereof with a myeloma cell line; a method for assaying NAIP by using these antibodies; and NAIP assay kits.
L'invention concerne des anticorps monclonaux qui reconnaissent spécifiquement la protéine NAIP inhibitrice de l'apoptose chez l'humain et présentent la séquence aminoacide représentée par SEQ. ID NO. 1. Ces anticorps monclonaux anti-NAIP sont produits respectivement par des hybridomes préparés par fusion de cellules de production d'anticorps de mammifères immunisés avec des immunogènes qui comprennent un polypeptide contenant la séquence aminoacide constituée des acides aminés des numéros 256 à 586 de la SEQ. ID NO. 1 ou un polypeptide contenant la séquence aminoacide constituée des acides aminés des numéros 841 à 1052 de la SEQ. ID NO. 1, ou leurs parties, et d'une lignée cellulaire myélomateuse. L'invention concerne une méthode de dosage de la protéine NAIP mettant en oeuvre ces anticorps, et des trousses de dosage de la protéine NAIP.
Ikeda Joh-E
Sakai Harumi
Japan Science And Technology Corporation
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
Toyo Boseki Kabushiki Kaisya
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