C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/30 (2006.01) A61K 39/00 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61K 49/00 (2006.01) A61K 51/10 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C07K 16/42 (2006.01) C07K 16/46 (2006.01) G01N 33/574 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2199740
Monoclonal antibodies, in particular 33.28 and 31.1, and chimeric antibodies, in particular mouse/human chimeric Chi #1 specific for glycoprotein antigens of colon carcinoma-associated antigens which are immunogenic in humans, are disclosed. Such antibodies, and fragments and derivatives thereof, are useful in immunodiagnosis and immunotherapy of human colon, breast, and ovarian cancer, and for purification of antigens which can serve as immunotherapeutic agents. Methods of detecting the colon carcinoma-associated antigen in a sample, and methods for treating subjects having colon, breast, and ovarian carcinomas are disclosed.
Anticorps monoclonaux, en particulier 33.28 et 31.1, et anticorps chimériques, en particulier Chi #1 chimérique de souris/humains spécifique d'antigènes glycoprotéiques d'antigènes associés au carcinome du côlon qui sont immunogènes chez les humains. Ces anticorps, ainsi que leurs fragments et dérivés, sont utiles dans l'immunodiagnostic et l'immunothérapie du cancer humain du côlon, du sein et des ovaires et pour purifier des antigènes qui peuvent servir d'agents immunothérapeutiques. Des procédés de détection d'antigènes associé au carcinome du côlon dans un prélèvement, et des procédés de traitement de sujets atteints de carcinomes du côlon, du sein et de l'ovaire sont également décrits.
Arlen Myron
Tsang Kwong Y.
Arlen Myron
Fetherstonhaugh & Co.
International Bioimmune Systems Inc.
Tsang Kwong Y.
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