C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
167/139, 167/37,
C12P 21/08 (2006.01) A61K 39/395 (2006.01) C07K 16/24 (2006.01) C12N 5/18 (2006.01) G01N 33/566 (2006.01) G01N 33/577 (2006.01)
Patent
CA 1337717
The invention relates to hybridoma cell lines which synthesize highly specific monoclonal antibodies (mAb) against human tumor necrosis factor (H-TNF), to monoclonal antibodies against H-TNF having an affinity constant for H-TNF greater than 109 l/mol, which does not cross react with lymphotoxin and neutralizing the cytotoxic activities of H-TNF, to methods isolating and detecting H-TNF in samples using said antibodies, and to pharmaceutical compositions which contain them. The present invention also relates to the hybrid cell line ECACC 87 050801 and to the monoclonal antibody AM-195 produced by this hybrid cell line. The present invention also relates to methods for isolating and detecting human tumor necrosis factor-alpha using the AM-195 antibody. The present invention further relates to pharmaceutical compositions which contain the monoclonal antibody AM-195.
546724
Emling Franz
Moeller Achim
Basf Aktiengesellschaft
Emling Franz
Moeller Achim
Robic
LandOfFree
Monoclonal antibodies against human necrosis factor (tnf) _... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Monoclonal antibodies against human necrosis factor (tnf) _..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Monoclonal antibodies against human necrosis factor (tnf) _... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1292041