Monoclonal antibodies against human tnf-binding protein i...

Details Monoclonal antibodies against human tnf-binding protein i... Monoclonal antibodies against human tnf-binding protein i...

C - Chemistry, Metallurgy

12

P

C12P 21/08 (2006.01) A61K 39/395 (2006.01) C07K 16/28 (2006.01) C12N 5/18 (2006.01) G01N 33/574 (2006.01) G01N 33/577 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2107340

-the invention concerns monoclonal antibodies,designated tbp-1, tbp-2 and tbp- 6, against the extracellular part of the hu- man 60 k1) TN tumour necrosis [actor receptor (TNF-BP1). These antibodies are suitable for use in highly semsitive immuno-as says for demonstrating the presence of TNF1-BP 1 in body fluids, including urine, and in cell-culture residues. The determination of the TNF-BP1 concentration as the basis for a diagnosis of pathological conditions associated with activation of the TNF re- ceptor system is thus particularly useful if the ~TNF concentration in the organism falls more rapidly than the TNF-BPI con- centration. In addition, tbp-1 and tbp-6 can he used to strengthen the protective action of TNF-BP1 against (~-TNF and/or (.beta.- TNF-

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