Monoclonal antibodies against human tumor necrosis factor...

C - Chemistry – Metallurgy – 12 – N

Patent

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C12N 5/18 (2006.01) A61K 39/395 (2006.01) C07K 16/24 (2006.01) C12P 21/08 (2006.01) G01N 33/577 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2058370

A monoclonal antibody is provided which is able to neutralize both human TNF a and TNF B, or a binding fragment thereof. A stable hybridoma cell line and progeny thereof are also provided which secrete such a monoclonal antibody. The monoclonal antibody or a fragment thereof may be used to detect the content of human TNF in a sample of body fluid. If a figure has to accompany the abstract, when the abstract is published, we indicate figure 7.

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