Monoclonal antibodies against metal chelates

Details Monoclonal antibodies against metal chelates Monoclonal antibodies against metal chelates

C - Chemistry, Metallurgy

07

K

167/41, 195/1.11

C07K 16/44 (2006.01) A61K 39/00 (2006.01) A61K 51/10 (2006.01) C07K 16/46 (2006.01) G01N 33/534 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1275952

ABSTRACT Monoclonal antibodies are described which exhibit specificity for the complex of a chelating agent and a specific metal as compared to the chelating agent itself or a complex of the agent with another metal. A monoclonal antibody is considered to exhibit specificity for a complex of a specific metal and chelating agent when the binding constant (KA) between the antibody and complex is an order of magnitude (ten times) greater than the KA of the antibody for the chelating agent alone or for a complex of the chelating agent with another metal. These monoclonal antibodies are useful for the conjugation of radionuclides to antibodies and for the purification of trace metals.

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