Monoclonal antibodies against nkg2a

Details Monoclonal antibodies against nkg2a Monoclonal antibodies against nkg2a

C - Chemistry, Metallurgy

07

K

C07K 16/28 (2006.01) A61K 39/395 (2006.01)

Patent

CA 2591059

The present invention relates to methods of treating immune disorders, particularly autoimmune or inflammatory disorders, and methods of producing antibodies and other compounds for use in therapeutic strategies for treating such disorders. Generally, the present methods involve the use of antibodies or other compounds that prevent the stimulation of NKG2A receptors on NK cells, leading to the lysis of dendritic cells that contribute to the pathology of the disorders.

L'invention concerne des procédés de traitement de troubles immunitaires, notamment des troubles auto-immunitaires ou inflammatoires, et des procédés de production d'anticorps et d'autres composés destinés à être utilisés dans des stratégies thérapeutiques en vue de traiter ces troubles. Généralement, les procédés de l'invention impliquent l'utilisation d'anticorps ou d'autres composés qui empêchent la simulation de récepteurs NKG2A sur des cellules NK, entraînant la lyse de cellules dendritiques qui contribue à la pathologie de ces troubles.

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