Monoclonal antibodies against non small cell lung cancer

Details Monoclonal antibodies against non small cell lung cancer Monoclonal antibodies against non small cell lung cancer

G - Physics

01

N

167/139, 167/37,

G01N 33/577 (2006.01) A61K 39/395 (2006.01) C07K 16/30 (2006.01)

Patent

CA 1230565

ABSTRACT OF THE DISCLOSURE Monoclonal antibodies 703D4 and 704Al detect human non-small cell lung cancer (non-SCLC) and distinguish non- SCLC from all other types of lung cancer and normal tissue cells. These two antibodies may be utilized in kit form to distinguish non-SCLC from other forms of lung cancer. These monoclonal antibodies bind to S35 methionine-incorporating protein doublets under reduced and unreduced conditions. The determinants bound by these antibodies on the 31 kilo- dalton protein are independent of each other as determined in radiolabelled competition assays.

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