Monoclonal antibodies against receptor induced binding sites

Details Monoclonal antibodies against receptor induced binding sites Monoclonal antibodies against receptor induced binding sites

C - Chemistry, Metallurgy

12

N

167/139, 167/41,

C12N 5/00 (2006.01) A61K 39/395 (2006.01) C07K 14/75 (2006.01) C07K 16/36 (2006.01) G01N 33/567 (2006.01) G01N 33/569 (2006.01) G01N 33/60 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2000044

ABSTRACT Receptor-induced binding sites (RIBS) expressed in a ligand when that ligand is bound in a complex with a receptor are disclosed, as are monoclonal antibodies that immunoreact with a RIBS but do not substantially immunoreact with either the ligand or the receptor when free in solution, and hybridomas that secrete such monoclonal antibodies. Anti-RIBS monoclonal antibodies, hybridomas secreting those antibodies, as well as methods of making and using such antibodies are particularly illustrated in regard to RIBS expressed by fibrinogen when that ligand is bound by the GPIIb/IIIa receptor molecule.

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