Monoclonal antibodies against receptor-induced binding sites

Details Monoclonal antibodies against receptor-induced binding sites Monoclonal antibodies against receptor-induced binding sites

C - Chemistry, Metallurgy

12

P

C12P 21/08 (2006.01) A61K 38/36 (2006.01) A61K 39/395 (2006.01) C07K 7/08 (2006.01) C07K 14/75 (2006.01) C07K 16/36 (2006.01) G01N 33/566 (2006.01) G01N 33/567 (2006.01) G01N 33/569 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2103893

Receptor-induced binding sites (RIBS) expressed in a ligand when that ligand is bound in a complex with a receptor are disclosed, as are monoclonal antibodies that immunoreact with a RIBS but do not substantially immunoreact with either the li- gand or the receptor when free in solution. Anti-RlBS monoclonal antibodies, hybridomas secreting those antibodies, as well as methods of making and using such antibodies are particularly illustrated in regard to RIBS expressed by fibrinogen when that li- gand is bound by the GPllb-llla receptor molecule on platelets.

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