Monoclonal antibodies against the extracellular domain of...

Details Monoclonal antibodies against the extracellular domain of... Monoclonal antibodies against the extracellular domain of...

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A61K 47/48 (2006.01) A61K 49/00 (2006.01) A61K 51/10 (2006.01) C07K 16/28 (2006.01) G01N 33/566 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2265927

Monoclonal antibodies, secreted by hybridoma cell lines, that are directed against an epitope of the extracellular domain of human VEGF-receptor KDR, methods of determining human VEGF-receptor KDR in cell lysates or tissue analysates and the use of the antibodies in analytical assays, in diagnostics and as carrier molecules for therapeutic substances, are described.

L'invention concerne des anticorps monoclonaux, sécrétés par des lignées cellulaires d'hybridomes, et dirigés contre un épitope du domaine extracellulaire du récepteur KDR (récepteur contenant le domaine d'insertion de kinase) de VEGF humain (facteur de croissance de l'endothélium vasculaire), ainsi que des procédés de détermination du récepteur KDR de VEGF humain dans des lysats cellulaires ou dans des analysats tissulaires, de même que l'utilisation de ces anticorps dans des dosages analytiques, dans des diagnostics et en tant que molécules porteuses de substances thérapeutiques.

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