C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/22 (2006.01) A61K 39/395 (2006.01)
Patent
CA 2715456
The subject invention relates to isolated proteins, particularly monoclonal antibodies, which bind and neutralize RGM A protein. Specifically, these antibodies have the ability to inhibit the binding of RGM A to its receptor and/or coreceptors. These antibodies or portions thereof of the invention are useful for detecting RGM A and for inhibiting RGM A activity, for example in a human suffering from a disorder including but not limited to multiple sclerosis, mammalian brain trauma, spinal cord injury, stroke, neurodegenerative diseases, and schizophrenia.
La présente invention porte sur des protéines isolées, en particulier des anticorps monoclonaux, qui se lient et neutralisent la protéine RGM A. De façon spécifique, ces anticorps ont l'aptitude d'inhiber la liaison de la RGM A à son récepteur et/ou ses corécepteurs. Ces anticorps ou parties de ceux-ci de l'invention sont utiles pour détecter la RGM A et pour inhiber l'activité de la RGM A, par exemple chez un être humain souffrant d'un trouble comprenant, mais sans y être limité, la sclérose en plaques, le traumatisme du cerveau d'un mammifère, la lésion de la moelle épinière, l'accident vasculaire cérébral, les maladies neurodégénératives et la schizophrénie.
Bardwell Phillip D.
Barlow Eve H.
Hsieh Chung-Ming
Leddy Mary R.
Mueller Bernhard K.
Abbott Gmbh & Co. Kg
Abbott Laboratories
Torys Llp
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