Monoclonal antibodies against the ypydvpdya epitope, process...

C - Chemistry – Metallurgy – 07 – K

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C07K 16/10 (2006.01) C12P 21/08 (2006.01) G01N 33/577 (2006.01) C07K 7/08 (2006.01) C07K 14/11 (2006.01)

Patent

CA 2270408

Monoclonal antibodies against the YPYDVPDYA epitope derived from the haemagglutinin of the human influenza virus are useful for detecting and isolating native haemagglutinin of the human influenza virus, modified haemagglutinin or haemagglutinin fusion proteins and have an affinity > 10 8 M-1, in particular from 10 9 to 10 10 M-1.

L'invention concerne des anticorps monoclonaux contre l'épitope YPYDVPDYA dérivés de l'hémagglutinine du virus de la grippe humaine et qui servent à dépister et à isoler l'hémagglutinine naturelle du virus de la grippe humaine, l'hémagglutinine modifiée ou des protéines hybrides de l'hémagglutinine. Ces anticorps ont une affinité supérieure à 10<8>M<-1>, comprise notamment entre 10<9> et 10<10>M<-1>.

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