C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/38 (2006.01) A61K 39/395 (2006.01) A61P 7/04 (2006.01) C12N 15/13 (2006.01) C12P 21/08 (2006.01)
Patent
CA 2733075
Isolated monoclonal antibodies that bind human tissue factor pathway inhibitor (TFPI) and the isolated nucleic acid molecules encoding them are provided. Pharmaceutical compositions comprising the anti-TFPI monoclonal antibodies and methods of treating deficiencies or defects in coagulation by administration of the antibodies are also provided. Methods of producing the antibodies are also provided.
La présente invention concerne des anticorps monoclonaux isolés qui se lient à l'inhibiteur de la voie du facteur tissulaire (TFPI) humain et les molécules d'acide nucléique isolées codant pour ceux-ci. La présente invention concerne en outre des compositions pharmaceutiques comprenant les anticorps monoclonaux anti-TFPI et des procédés de traitement de déficiences ou de défauts de coagulation par administration des anticorps. La présente invention concerne en outre des procédés de production des anticorps.
Jiang Haiyan
Liu Bing
Murphy John E.
Pan Junliang
Wang Zhuozhi
Bayer Healthcare Llc
Mbm Intellectual Property Law Llp
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