C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
167/37, 195/1.1,
C12P 21/08 (2006.01) C07K 16/30 (2006.01) C12N 11/02 (2006.01) G01N 33/574 (2006.01) G01N 33/577 (2006.01)
Patent
CA 1335796
The present invention is concerned with novel mono- clonal antibodies which define a glycolipid antigen as- sociated with human non-small cell lung carcinomas ("NSCLC") and certain other human carcinomas. The anti- bodies bind to normal human cells to a much lesser de- gree than to tumor cells. The antibodies find use in diagnostic methods such as the detection of malignant cells associated with NSCLC and in therapeutic methods. Also disclosed is a novel glycolipid antigen. The in- vention also comprises a method for determining the pre- sence of a malignant condition in lung tissue and other human tissue. The method involves examining the human tissue for the presence of a glycolipid antigen having the terminal carbohydrate sequence: GalNAc.beta.1?4Gal.beta.1?3GalNAc.beta.1?4Gal.beta.1?R.
497251
Brown Joseph Patrick
Hellstrom Ingegerd
Hellstrom Karl Erik
Horn Diane
Linsley Peter
Oncogen
Osler Hoskin & Harcourt Llp
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