C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
195/1.109
C12P 21/08 (2006.01) C07K 14/47 (2006.01) C07K 16/30 (2006.01) C12N 5/18 (2006.01) G01N 33/574 (2006.01) A61K 38/00 (2006.01)
Patent
CA 1312025
ABSTRACT OF THE DISCLOSURE The present invention is concerned with novel monoclonal antibodies which bind strongly to a protein antigen associated with human non-small cell lung carcinomas ("NSCLC"), human small cell lung carcinomas and certain other human carcinomas including many carcinomas of the colon and breast. The antibodies bind to normal human cells to a mucn lesser degree than to tumor cells. The antibodies find use both in diagnostic methods such as the detection of malignant cells associated with NSCLC and in therapeutic methods for treatment of humans with NSCLC and certain other human carcinomas. Also disclosed is a novel 110,000 dalton glycoprotein antigen found on the cell surface of human non- small lung carcinoma tumor cells and on cells from certain other human cancers. The amino terminal amino acid sequence of this antigen is: Image in which X represents an unidentified amino acid.
530728
Brown Joseph P.
Hellstrom Ingegerd
Hellstrom Karl Erik
Marquardt Hans
Oncogen
Ridout & Maybee Llp
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