C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/18 (2006.01) A61K 39/395 (2006.01) A61K 49/16 (2006.01) A61K 51/10 (2006.01) C07K 14/435 (2006.01) C07K 16/30 (2006.01) C07K 16/42 (2006.01) C12N 5/12 (2006.01) G01N 33/554 (2006.01) G01N 33/574 (2006.01)
Patent
CA 2427643
The invention provides new monoclonal antibodies and binding fragments thereof which recognize and immunoreact with cell surface antigens found on small cell lung cancer (SCLC) cells. The antibodies have tumor specificity and are useful for therapy, diagnosis, monitoring, detecting and imaging of SCLC disease and of patients having SCLC disease. The antibody-recognized SCLC-specific surface antigens can serve as targets for detecting, diagnosing, inhibiting or killing SCLC cells.
L'invention concerne des nouveaux anticorps monoclonaux et des fragments de liaison de ceux-ci, qui reconnaissent les antigènes de surface que l'on trouve dans les cellules du cancer à petites cellules (SCLC), et qui sont immunoréactifs avec ceux-ci. Les anticorps de l'invention sont spécifiques de certaines tumeurs et sont utiles pour la thérapie, le diagnostic, le contrôle, la détection et l'imagerie de maladies du type SCLC et de patients souffrant de SCLC. Les antigènes de surface spécifiques de SCLC reconnus par les anticorps peuvent servir de cibles pour la détection, le diagnostic, l'inhibition ou l'élimination des cellules de SCLC.
Immunocellular Therapeutics Ltd.
Molecular Discoveries L.l.c.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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