C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/18 (2006.01) C07K 14/47 (2006.01) C12N 5/20 (2006.01) G01N 33/574 (2006.01) G01N 33/577 (2006.01) G01N 33/68 (2006.01) C07K 16/40 (2006.01)
Patent
CA 2606250
Compositions and methods for diagnosing high-grade cervical disease in a patient sample are provided. The compositions include monoclonal antibodies, and variants and fragments thereof, that specifically bind to MCM2. Monoclonal antibodies having the binding characteristics of an MCM2 antibody of the invention are further provided. Hybridoma cell lines that produce an MCM 2 monoclonal antibody of the application are also disclosed herein. The compositions find use in practicing methods for diagnosing high-grade cervical disease comprising detecting overexpression of MCM2 in a cervical sample from a patient. Kits for practicing the methods of the application are further provided. Polypeptides comprising the amino acid sequence for an MCM2 epitope and methods of using these polypeptides in the production of antibodies are also encompassed by the present application.
L'invention concerne une nouvelle classe de composés, des compositions pharmaceutiques comprenant ces composés et des méthodes d'utilisation de ces composés pour traiter ou pour prévenir des maladies ou des troubles associés à une activité de kinases anormale ou déréglée, en particulier des maladies ou des troubles impliquant une activation anormale de AIk, AbI, BRK, BIk, BMX, CSK, c-Src, c-Raf, EGFR, Fes, FGFR3, Fms, Fyn, IGF-IR, IR, IKKa, IKKß, JAK2, JAK3, KDR, Lck, Met, p70S6k, Ros, Rskl, SAPK2a, SAPK2ß, SAPK3, SIK, Tie2, TrkB et/ou WNK3 kinases.
Fischer Timothy J.
Malinowski Douglas P.
Taylor Adriann J.
Smart & Biggar
Tripath Imaging Inc.
LandOfFree
Monoclonal antibodies and methods for their use in the... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Monoclonal antibodies and methods for their use in the..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Monoclonal antibodies and methods for their use in the... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-2029467