C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/18 (2006.01) A61K 38/04 (2006.01) A61K 39/395 (2006.01) C07K 7/04 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C07K 16/28 (2006.01) C12N 5/12 (2006.01) C12N 5/16 (2006.01) C12N 15/13 (2006.01) C12N 15/63 (2006.01) G01N 33/569 (2006.01) G01N 33/574 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2367901
The invention concerns novel DNA and amino acid sequences of monoclonal antibodies (mAbs) raised against lymphoblastoid cells and peptides to which the mAbs bind to. The invention also concerns diagnostic assays using said antibodies or peptides for detecting individuals with a high probability of having a malignant disease and, at times, for detecting an individual having a specific malignant disease. The invention further concerns pharmaceutical compositions comprising the mAbs or peptides of the invention for use in the treatment of various malignant diseases as well as methods for the treatment of malignant diseases using the mAbs or peptides of the invention.
L'invention concerne un nouvel ADN et des séquence d'acides aminés d'anticorps monoclonaux (mAbs) agissant contre des cellules et des peptides lymphoblastoïdes auxquels les anticorps monoclonaux se lient. L'invention concerne également des dosages de diagnostic faisant intervenir ces anticorps ou ces peptides pour détecter chez des individus une forte probabilité de souffrir d'une affection maligne et, parfois, pour détecter chez un individu une affection maligne spécifique. L'invention concerne en outre des compositions pharmaceutiques comprenant les anticorps monoclonaux ou les peptides selon l'invention destinés à s'utiliser dans le traitement de nombreuses affections malignes, ainsi que des méthodes de traitement d'affections malignes grâce aux anticorps monoclonaux ou peptides selon l'invention.
Hardy Britta
Novogrodsky Abraham
Marks & Clerk
Mor-Research Applications Ltd.
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