C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/70 (2006.01)
Patent
CA 2637837
The present application provides monoclonal antibodies that specifically bind to the hemagglutinin of avian influenza virus subtype H5, as well as monoclonal antibodies capable of blocking at least 50% of the hemagglutinin binding activity of these monoclonal antibodies. Such antibodies are useful, for example, in the detection, diagnosis, prevention, and treatment of avian influenza virus. Also provided herein are hybridoma cell lines, isolated nucleic acid molecules, and short peptides related to the monoclonal antibodies provided herein, and pharmaceutical compositions and kits containing the monoclonal antibodies provided herein.
La présente invention concerne des anticorps monoclonaux qui se lient spécifiquement à l'hémagglutinine de la sous-classe H5 du virus de la grippe aviaire, ainsi que des anticorps monoclonaux capables de bloquer au moins 50 % de l'activité de liaison à l'hémagglutinine de ces anticorps monoclonaux. Par exemple, de tels anticorps sont utiles pour détecter, diagnostiquer, prévenir et traiter le virus de la grippe aviaire. L'invention concerne aussi des lignées cellulaires d'hybridome, des molécules isolées d'acide nucléique et des peptides courts associés auxdits anticorps monoclonaux, et des compositions pharmaceutiques et des trousses qui contiennent lesdits anticorps monoclonaux.
Chen Yixin
Ge Shengxiang
Luo Wenxin
Xia Ningshao
Zhang Jun
Hx Diagnostics Inc.
Smart & Biggar
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