Monoclonal antibodies, cross-reactive antibodies and method...

Details Monoclonal antibodies, cross-reactive antibodies and method... Monoclonal antibodies, cross-reactive antibodies and method...

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A61K 39/395 (2006.01) C07K 14/705 (2006.01) C07K 16/00 (2006.01) C07K 16/28 (2006.01) C07K 16/46 (2006.01) C12N 5/16 (2006.01) C12N 15/85 (2006.01) C12P 21/08 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2328498

A method of making monoclonal antibodies according to a mixed antigen immunization protocol is described. In addition, antibodies obtainable by the method are disclosed which specifically cross-react with two or more different receptors to which Apo-2 ligand (Apo-2L) can bind.

L'invention concerne un procédé pour fabriquer des anticorps monoclonaux selon un protocole d'immunisation d'antigènes mixtes. En outre, on a découvert que les anticorps obtenus par ce procédé entrent en réaction de manière croisée avec deux ou plusieurs récepteurs différents auxquels peut se lier le ligand Apo-2 (Apo-2L).

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