C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
167/37, 530/15.0
C12P 21/08 (2006.01) C07H 21/00 (2006.01) C07K 14/705 (2006.01) C07K 16/18 (2006.01) C07K 16/28 (2006.01) C07K 16/42 (2006.01) C12N 5/12 (2006.01) C12Q 1/68 (2006.01) G01N 33/577 (2006.01)
Patent
CA 2020543
ABSTRACT MONOCLONAL ANTIBODIES DIRECTED AGAINST ACTIVATED MICROGLIA CELLS, HYBRIDOMAS SECRETING THESE MONOCLONAL ANTIBODIES, ANTIGEN RECOGNIZED BY THESE MONOCLONAL ANTIBODIES AND THEIR APPLICATIONS The invention relates to a monoclonal antibody which has the combination of the following properties: - it forms an immunological complex with a non- phosphorylated epitope of an antigen belonging to activated microglial cells of the central nervous system and released from a sonicated NFT preparation, itself isolated from the cerebral cortex obtained from a patient having Alzheimer's disease, - it forms an immunological complex with histiocytes and macrophages of the central nervous system, said monoclonal antibody can be used for the diagnosis in vitro of brain diseases involving activated microglial cells. No figure
Gheuens Jan
Van Heuverswyn Hugo
Fetherstonhaugh & Co.
Gheuens Jan
N.v. Innogenetics S.a.
Van Heuverswyn Hugo
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