Monoclonal antibodies directed against the microtubule-...

Details Monoclonal antibodies directed against the microtubule-... Monoclonal antibodies directed against the microtubule-...

C - Chemistry, Metallurgy

12

N

C12N 5/18 (2006.01) C07K 14/435 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) G01N 33/566 (2006.01) G01N 33/577 (2006.01)

Patent

CA 2150816

The invention relates to a monoclonal antibody which forms an immunological complex with an epitope of an antigen belonging to normal human tau protein as well as abnormally phosphorylated human tau protein, with said tau protein being liable to be obtained from a brain homogenate, itself isolated from human cerebral cortex. The monoclonal antibodies of the invention can be used to detect tau and abnormally phosphorylated tau in brain extracts and in unconcentrated cerebrospinal fluid.

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