G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/574 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01) C07K 16/30 (2006.01)
Patent
CA 2737758
It is disclosed herein that condroitin sulfate proteoglycan 4 (CSPG4), also known as high molecular weight melanomal associated antigen, is overexpressed on basal breast carcinoma cells (BBC), specifically triple negative basal breast carcinoma cells (TNBC). Methods for detecting basal breast cancer in a subject are disclosed. Methods are also disclosed for inhibiting the growth of a basal breast cancer cell. These methods include contacting the basal breast cancer cancer cell with an effective amount of an antibody that specifically binds CSPG4. Additional treatment methods, and the use of antibody panels, are also described herein.
Selon l'invention, le condroïtine-sulfate 4 protéoglycane (CSPG4), également appelé antigène associé aux mélanomes de poids moléculaire élevé, est sur-exprimé dans des cellules de carcinome mammaire de type basal, en particulier dans des cellules de carcinome mammaire de type basal triple négatif. L'invention concerne des méthodes de diagnostic du cancer du sein de type basal chez une patiente. L'invention concerne également des méthodes d'inhibition de la croissance d'une cellule cancéreuse mammaire de type basal. Ces méthodes consistent à mettre en contact la cellule cancéreuse avec une quantité efficace d'un anticorps se liant spécifiquement à CSPG4. L'invention concerne encore des méthodes de traitement supplémentaires ainsi que l'utilisation de groupes d'anticorps.
Ferrone Soldano
Wang Xinhui
Smart & Biggar
University Of Pittsburgh - Of The Commonwealth System Of Higher
University Of Pittsburgh-Of The Commonwealth System Of Higher Ed
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