Monoclonal antibodies for human non-small cell lung carcinomas

Details Monoclonal antibodies for human non-small cell lung carcinomas Monoclonal antibodies for human non-small cell lung carcinomas

C - Chemistry, Metallurgy

12

N

167/43, 167/45,

C12N 5/18 (2006.01) C07K 16/30 (2006.01) G01N 33/574 (2006.01) G01N 33/577 (2006.01)

Patent

CA 1337755

The present invention is concerned with two novel mon- oclonal antibodies which define carbohydrate antigens asso- ciated with human non-small cell lung carcinomas ("NSCLC") and certain other human carcinomas. The antibodies bind to normal human cells to a much lesser degree than to tumor cells. The antibodies find use in diagnostic methods such as the detection of malignant cells associated with NSCLC and in therapeutic methods. The invention also comprises a method for determining the presence of a malignant condi- tion in the lung of a subject. The method involves examin- ing tissue from the subject for the presence of antigens which are Lex or Ley antigen or which have the characteris- tics of Ley and Lex.

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