Monoclonal antibodies for tumor treatment

Details Monoclonal antibodies for tumor treatment Monoclonal antibodies for tumor treatment

C - Chemistry, Metallurgy

07

K

C07K 16/30 (2006.01) A61K 39/395 (2006.01)

Patent

CA 2715166

The present invention relates to methods for inhibiting tumor growth, increasing survival of a subject having a tumor and inducing protection against tumor recurrence in a mammal. The methods comprise administering a humanized monoclonal antibody comprising CDR regions derived from the murine monoclonal antibody designated mBAT-1, in combination with at least one chemotherapeutic agent.

La présente invention porte sur des procédés pour inhiber la croissance tumorale, augmenter la survie d'un sujet ayant une tumeur et induire une protection contre la réapparition d'une tumeur chez un mammifère. Les procédés comprennent l'administration d'un anticorps monoclonal humanisé comprenant des régions CDR issues de l'anticorps monoclonal de murin désigné mBAT-1, en association avec au moins un agent chimiothérapeutique.

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