C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/10 (2006.01) A61P 31/16 (2006.01) G01N 33/569 (2006.01) G01N 33/577 (2006.01)
Patent
CA 2725627
A monoclonal antibody directed against the influenza A virus is described, which is capable of binding human and animal isolates of influenza A viruses expressing the H1 -subtype hemagglutinin. A preferred embodiment is the antibody designated as Fab49, which shows a neutralizing activity against a plurality of influenza A virus isolates expressing the H1- subtype hemagglutinin, including animal-derived isolates. Anti-idiotype antibodies directed against the monoclonal antibody of the invention, immunogenic or vaccine compositions comprising the monoclonal antibody of the invention are also described, as well as therapeutic, prophylactic and diagnostic applications for the monoclonal antibody of the invention. The monoclonal antibody of the invention can also be employed for testing antibody preparations to be used as vaccines.
La présente invention concerne un anticorps monoclonal dirigé contre le virus de la grippe A, qui est capable de se lier à des isolats humains ou d'animaux des virus de la grippe A exprimant l'hémagglutinine de sous-type H1. Un mode de réalisation préféré est l'anticorps désigné par Fab49, qui révèle une activité de neutralisation contre une pluralité d'isolats du virus de la grippe A exprimant l'hémagglutinine de sous-type H1, y compris des isolats dérivés d'animaux. L'invention concerne également des anticorps anti-idiotypes dirigés contre l'anticorps monoclonal de l'invention, des compositions immunogènes ou de vaccins comprenant l'anticorps monoclonal de l'invention, ainsi que des applications thérapeutiques, prophylactiques et diagnostiques pour l'anticorps monoclonal de l'invention. L'anticorps monoclonal de l'invention peut également être utilisé pour tester des préparations d'anticorps à utiliser comme vaccins.
Burioni Roberto
Clementi Massimo
Macrae & Co.
Pomona Ricerca S.r.l.
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