Monoclonal antibodies (mabs) against tumor-associated...

Details Monoclonal antibodies (mabs) against tumor-associated... Monoclonal antibodies (mabs) against tumor-associated...

C - Chemistry, Metallurgy

12

P

167/139, 167/37,

C12P 21/08 (2006.01) A61K 47/48 (2006.01) A61K 49/00 (2006.01) A61K 51/10 (2006.01) C07K 14/705 (2006.01) C07K 16/30 (2006.01) G01N 33/577 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2012993

The invention relates to marine monoclonal anti- bodies (MAbs), A, B, C and D, which are directed against tumor-associated antigens. The nearly complete nucleotide sequences of the v genes of these MAbs are described, so that the relevant variable domains can be put together to give chimeric MAbs, or "humanized" MAbs are obtained by inserting the hypervariable regions (complementarity determining regions = CDR) into a human MAb framework. Antibody constructs of this type can be employed in human therapy and in vivo diagnosis without the disadvantages observed with marine MAbs.

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