C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
167/139, 167/37,
C12P 21/08 (2006.01) A61K 39/395 (2006.01) C12N 5/12 (2006.01) C12Q 1/68 (2006.01) G01N 33/577 (2006.01)
Patent
CA 2005121
ABSTRACT The present invention relates to monoclonal antibodies which recognize defined regions of the T-cell receptor (TCR). In a specific embodiment, the invention provides monoclonal antibodies which are reactive with a constant region of the alpha chain of the TCR. In particular embodiments, the invention relates to two monoclonal antibodies, termed .alpha.Fl and .alpha.F2, which react with two different epitopes on the framework region of the monomer of the TCR molecule. In another specific embodiment, the invention is directed to monoclonal antibodies reactive with a variable region of the beta chain of the TCR. In particular, the invention provides two monoclonal antibodies, termed W112 and 2Dl, which react with .beta. chain variable regions V.beta.5.3 and V.beta.8.1, respectively. In another specific embodiment, the invention is directed to monoclonal antibodies reactive with a variable region of the delta chain of the TCR. In particular, the invention provides monoclonal antibody .delta.TCSl, isotype IgG2a. The monoclonal antibodies of the invention have value in diagnosis and therapy and are useful tools for study of the immune system.
Henry Larry D.
Ip Stephen H.
Ko Jone-Long
Kung Patrick C.
Rittershaus Charles W.
Astra Ab
Osler Hoskin & Harcourt Llp
T. Cell Sciences Inc.
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