Monoclonal antibodies reactive with normal and oncogenic...

Details Monoclonal antibodies reactive with normal and oncogenic... Monoclonal antibodies reactive with normal and oncogenic...

C - Chemistry, Metallurgy

12

N

195/1.109

C12N 15/02 (2006.01) C07K 14/82 (2006.01) C07K 16/32 (2006.01)

Patent

CA 1297048

TITLE NN-O211 MONOCLONAL ANTIBODIES REACTIVE WITH NORMAL AND ONCOGENIC FORMS OF THE ras p21 PROTEIN ABSTRACT OF THE DISCLOSURE Monoclonal antibodies reactive with normal an oncogenic forms of the ras p21 protein. The antibodies are secreted by hybridomas obtained by immunizing mice with the Ha ras p21 protein containing the arginine mutation at position 12 of the protein. The antibodies and immunoreactive fragments thereof of useful for detection, diagnosis, quantitation, staging and classification of normal and activated ras p21s in normal tissues, malignant and premalignant lesions.

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