Monoclonal antibodies recognizing the epidermal growth...

Details Monoclonal antibodies recognizing the epidermal growth... Monoclonal antibodies recognizing the epidermal growth...

C - Chemistry, Metallurgy

12

P

C12P 21/08 (2006.01) A61K 39/395 (2006.01) C12N 5/20 (2006.01)

Patent

CA 2116753

The present invention relates to a monoclonal antibodies capable of recognizing the EGF receptor in human placenta or A-431 cells with high affinity and capable of inhibiting EGF binding to the receptor. The monoclonal antibodies also has the ability to produce antibody dependent cellular cytotoxicity; to develop complement-mediated cytotoxic activity; to inhibit tumoral growth in certain cell lines and to show a synergetic effect to inhibit these cell lines proliferation when they are in combination with gangliosides or monoclonal antibodies against EGF.

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