Monoclonal antibodies recognizing tie-receptor and their use

Details Monoclonal antibodies recognizing tie-receptor and their use Monoclonal antibodies recognizing tie-receptor and their use

C - Chemistry, Metallurgy

07

K

C07K 16/40 (2006.01) A61K 39/395 (2006.01) A61K 49/00 (2006.01) A61K 51/10 (2006.01) A61P 35/00 (2006.01) C07K 16/28 (2006.01) C07K 16/46 (2006.01) C12N 5/20 (2006.01) G01N 33/573 (2006.01) G01N 33/574 (2006.01) G01N 33/577 (2006.01) G01N 33/537 (2006.01) G01N 33/58 (2006.01)

Patent

CA 2185043

Novel antibodies, which are reactive with Tie, a receptor tyrosine kinase found in endothelial cells and in certain tumor cell populations are described. Anti-Tie monoclonal antibodies are described and the monoclonal antibody 3C4C7G6 is provided, as well as the hybridocma cell line (DSM ACC2159) which produces it. The antibodies are useful as diagnostic tools for detecting neoplastic diseases involving tumor angiogenesis, wound healing and a variety of other angiogenesis associated diseases and for radiological imaging of blood vessels. In addition, the disclosed antibodies are useful as therapeutic agents.

La présente invention concerne de nouveaux anticorps qui réagissent avec "Tie", une tyrosine kinase réceptrice que l'on rencontre dans les cellules endothéliales et dans certaines populations de cellules tumorales. L'invention porte aussi sur des anticorps monoclonaux anti-"Tie", sur l'anticorps monoclonal 3C4C7G6 et sur la lignée cellulaire hybridome (DSM ACC2159) qui le produit. Ces anticorps servent d'outil diagnostique pour le dépistage de maladies néoplasiques avec angiogenèse de tumeurs, d'agent de cicatrisation, d'agent de dépistage d'une variété d'autres maladies associées à l'angiogenèse et d'outil de visualisation radiologique des vaisseaux sanguins. Ils peuvent, en outre, servir d'agents thérapeutiques.

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