Monoclonal antibodies specific for pancreatic neoplasia cells

Details Monoclonal antibodies specific for pancreatic neoplasia cells Monoclonal antibodies specific for pancreatic neoplasia cells

C - Chemistry, Metallurgy

07

K

C07K 16/30 (2006.01) A61P 35/00 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2735881

Isolated monoclonal antibodies are disclosed herein that specifically bind a cell surface antigen expressed on the human pancreatic cancer cells or precancerous pan-creatic cancer cells. Humanized forms of these antibodies, functional fragments of these anti-bodies, and hybridomas producing these anti-bodies are also disclosed. The antibodies can be conjugated to an effector molecule, such as a detectable marker, a therapeutic agent, or a toxin. The antibodies can be used for in vitro or in vivo pancreatic cancer diagnosis or dis-ease monitoring via detection of pancreatic cancer cells or the pancreatic cancer cell sur-face antigen. Methods of treating a pancreatic cancer by administration of the antibodies are also disclosed.

La présente invention concerne des anticorps monoclonaux isolés qui se lient spécifiquement à un antigène de surface cellulaire exprimé sur des cellules cancéreuses pancréatiques humaines ou des cellules cancéreuses pancréatiques précancéreuses. L'invention concerne également des formes humanisées de ces anticorps, des fragments fonctionnels de ces anticorps, et des hybridomes produisant ces anticorps. Les anticorps peuvent être conjugués à une molécule effectrice, tel quun marqueur détectable, un agent thérapeutique, ou une toxine. Les anticorps peuvent être utilisés pour un diagnostic ou un suivi de maladie cancéreuse pancréatique in vitro ou in vivo par le biais de la détection de cellules cancéreuses pancréatiques ou d'un antigène de surface cellulaire cancéreuse pancréatique. Linvention concerne également des procédés de traitement dun cancer pancréatique par ladministration des anticorps.

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