C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
195/1.112
C12N 5/02 (2006.01) A61K 39/395 (2006.01) C07K 16/28 (2006.01) A61K 38/00 (2006.01)
Patent
CA 1179952
MONOCLONAL ANTIBODIES SPECIFIC FOR THE HUMAN TRANSFERRIN RECEPTOR GLYCOPROTEIN ABSTRACT Monoclonal antibodies are produced specific for the cell surface transferrin receptor of human cells. Animals are inoculated with purified human transferrin receptor glycoprotein, human hematopoietic cells or fragments thereof, and spleen cells obtained from the animals are fused with myeloma cells to produce hybridomas. The hybridomas are cultured as clones, and antibodies obtained from the individual clones are tested for their specificty for human transferrin receptor. Clones which produce antibodies specific for the receptor and that interfere with or block transferrin binding are selected for further culturing to produce the antibody, and the antibody is obtained from the culture growth medium or from ascitic fluid of an animal bearing a tumor of the hybridoma. Monoclonal antibodies which block transferrin binding are useful in regulating cell growth and for other therapeutic uses.
413450
Macrae & Co.
Salk Institute For Biological Studies (the)
LandOfFree
Monoclonal antibodies specific for the human transferrin... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Monoclonal antibodies specific for the human transferrin..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Monoclonal antibodies specific for the human transferrin... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1265567