Monoclonal antibodies specific for the psa-act complex

Details Monoclonal antibodies specific for the psa-act complex Monoclonal antibodies specific for the psa-act complex

C - Chemistry, Metallurgy

07

K

C07K 16/40 (2006.01) A61K 39/00 (2006.01) C07K 14/81 (2006.01) C07K 16/38 (2006.01) C12N 5/20 (2006.01) C12N 9/64 (2006.01) C12P 21/08 (2006.01) G01N 33/577 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2268274

Monoclonal antibodies have been developed which specifically bind the PSA-ACT complex without significant cross-reactivity with PSA, ACT or CG-ACT. The antibodies were generated using a unique immunogen comprising a PSA-ACT complex having bound to monoclonal antibodies against PSA and monoclonal antibodies against ACT. It is theorized that the antibodies against PSA and ACT block immunodominant sites on the PSA-ACT complex. The antibodies generated against the unique immunogen specifically bind the PSA-ACT complex, but have no significant cross-reactivity with either PSA or ACT. The monoclonal antibodies of the present invention can be used in immunoassays to specifically detect PSA-ACT in a sample.

L'invention concerne des anticorps monoclonaux qui se lient spécifiquement au complexe PSA-ACT sans présenter de réactivité croisée significative avec PSA, ACT ou CG-ACT. On génère les anticorps en faisant appel à un immunogène unique comprenant un complexe PSA-ACT présentant un lien avec des anticorps monoclonaux contre PSA et des anticorps monoclonaux contre ACT. Selon certaines théories, les anticorps contre PSA et ACT bloquent des sites immunodominants dans le complexe PSA-ACT. Les anticorps générés contre l'immunogène unique se lient spécifiquement au complexe PSA-ACT, mais ne présentent de réactivité croisée significative ni avec PSA ni avec ACT. Les anticorps monoclonaux de la présente invention sont susceptibles de s'utiliser dans des dosages immunologiques afin de détecter spécifiquement PSA-ACT dans un échantillon.

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