Monoclonal antibodies specific to endothelial cell cadherins...

Details Monoclonal antibodies specific to endothelial cell cadherins... Monoclonal antibodies specific to endothelial cell cadherins...

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A01K 67/027 (2006.01) A61K 38/08 (2006.01) A61K 38/17 (2006.01) A61K 39/39 (2006.01) A61K 39/395 (2006.01) C07K 7/06 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C07K 16/46 (2006.01) C12N 5/16 (2006.01) C12N 15/11 (2006.01) C12N 15/13 (2006.01) G01N 33/53 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2245956

A new VE-cadherin molecule is provided. Monoclonal antibodies that specifically bind to and neutralize an extracellular domain of a VE-cadherin molecule are provided. In vitro and in vivo methods of using these antibodies are also provided.

Nouvelle molécule de cadhérine endothéliale vasculaire (VE). On décrit des anticorps monoclonaux ayant une capacité spécifique de liaison et de neutralisation par rapport à un domaine extracellulaire d'une molécule de cadhérine de type VE. On décrit aussi des procédés in vitro et in vivo d'utilisation de ces anticorps.

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