Monoclonal antibodies, synthetic and biotechnological...

Details Monoclonal antibodies, synthetic and biotechnological... Monoclonal antibodies, synthetic and biotechnological...

C - Chemistry, Metallurgy

07

K

C07K 16/28 (2006.01) A01K 67/00 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) C12N 5/16 (2006.01) C12N 15/13 (2006.01) C12N 15/63 (2006.01) G01N 33/577 (2006.01)

Patent

CA 2373274

Monoclonal antibodies, synthetic and biotechnological derivatives thereof (ScFv or others) are able to recognise the NGF high affinity receptor, TrkA, and act as NGF-antagonist molecules. Pharmacological compositions for therapy, gene therapy, diagnostics of neurological pathologies are also described. Transgenic animal models to study such pathologies are also described.

L'invention concerne des anticorps monoclonaux et des dérivés synthétiques et biotechnologiques de ceux-ci (ScFv ou autre), qui sont capables de reconnaître le récepteur haute affinité du facteur NGF, ci-après dénommé TrkA, et de faire office de molécules antagonistes de ce facteur NGF. Cette invention concerne également des compositions pharmaceutiques utilisées en thérapie et en thérapie génique, ou pour diagnostiquer des pathologies neurologiques. Cette invention concerne enfin des modèles animaux transgéniques permettant d'étudier ces pathologies.

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