C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/00 (2006.01) A01N 37/36 (2006.01) A61K 31/655 (2006.01) C07K 16/12 (2006.01) G01N 33/53 (2006.01)
Patent
CA 2475774
Cross-reactive monoclonal antibodies are provided which are generated from peptides from Enterococcus faecalis, including the ACE40 and the ACE19 protein, and the CNA19 peptide from Staphylococcus aureus, and which can bind to the collagen-binding proteins from bacteria and from a variety of species including enterococcal bacteria, staphylococcal bacteria and streptococcal bacteria. These monoclonal antibodies may then be formed into suitable pharmaceutical compositions, and they are thus particularly effective in providing methods of treating or preventing bacterial infections from a wide range of bacterial species.
La présente invention a trait à des anticorps monoclonaux à réaction croisée qui sont générés à partir de peptides dérivés de Enterococcus faecalis, comprenant la protéine ACE40 et ACE19, et le peptide CNA19 dérivé de Staphylococcus aureus, et qui peuvent se lier aux protéines de liaison de collagène dérivées de bactéries et d'une variété comprenant des bactéries d'entérocoques, des bactéries de staphylocoques et des bactéries de streptocoques. Ces anticorps monoclonaux peuvent ensuite être transformés en compositions pharmaceutiques appropriées, et ils sont donc particulièrement efficaces pour fournir des procédés de traitement ou de prévention d'infections bactériennes provoquées par une grande variété d'espèces bactériennes.
Giampiero Pietrocola
Speziale Pietro
Visai Livia
Blake Cassels & Graydon Llp
Universita' Degli Studi Di Pavia
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